March , 2019 Vol 1 issues 1
Original Research Article by Agubata CO, Ottah OG
Development, characterization and ex vivo studies of transdermal patches for the delivery of diazepam using hypromellose, polyvinyl alcohol and cassava starch composite polymers

Transdermal drug delivery systems are basically patches or films applied to an intact skin to deliver bioactive substances at controlled rate to the blood through the skin. The aim of this study is to investigate the physico-chemical, mechanical and permeation properties of diazepam transdermal delivery patches. Diazepam transdermal films were prepared with blends of hydroxypropyl methylcellulose (Hypromellose, HPMC) and extracted cassava starch using solvent casting technique. Different transdermal films were also produced using polyvinyl alcohol (PVA) as film- former. The patches were evaluated for stability, thickness, folding endurance, moisture uptake and loss, elongation break, swelling index and ex vivo skin...

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