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July , 2019 Vol 1 issues 2
Original Research Article
Antifungal properties of ethanol extract of vernonia amygdalina stem and the effect on electrolyte status in normal and monosodium glutamate-intoxicated rats

This study investigated the antifungal properties of the extract of Vernonia amygdalina stem and its effect on the electrolyte status of normal and Monosodium Glutamate (MSG) intoxicated rats. In vitro antifungal property of the extract was tested. The serum electrolytes statuses of treated and non-treated MSG-intoxicated rats were evaluated. The results indicated the susceptibility of all the fungi used to the ethanol extract of Vernonia amygdalina stem. Extract inhibition of Fusarium spp showed a higher significant (*p <0.05) zone of inhibition compared to ketoconazone. Serum chemistry showed that there was no significant difference (*p < 0.05) in the serum levels of bicarbonate, calcium and sodium at all doses tested. There was significant (*p < 0.05) increase in the serum potassium level at 400 mg/kg b.w. of the extract compared to the control. Significantly (*p < 0.05) raised sodium and calcium levels were observed in animals treated with 200mg/kg body weight. However, the elevated values were brought close to those of control at the dose of 400 mg/kg b.w. The studied extract exhibited considerable antifungal activity even against Fusarium spp. which the standard drug had no activity against. It was also found out that the administration of ethanol extract of Vernonia amygdalina stem did not alter the levels of serum electrolyte.

ISSN: 2659 - 1472


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