The root of Entada africana L was extracted with methanol, ethyl acetate and hexane. The extracts obtained were then screened for antibacterial activity against six wound isolates; Staphylococcus aureus, Streptococcus pyogenes, Proteus mirabilis, Pseudomonas florescence, Klebsiella pneumonia and Escherichia coli. The results of this study showed that the methanol root extract of Entada africana produced the highest antibacterial activity, active on four out of the six organisms tested while that of hexane and ethyl acetate were only active on three organisms. Also, ethyl acetate extract produced a mild inhibition on P. florescence at 100mg/ml. The best inhibitory potential produced by the methanol extract was observed on S. aureus with minimum inhibitory concentration (MIC) value of 1.5 mg/ml, followed by Streptococcus pyogenes and Klebsiella pneumonia both with values of 6.25 mg/ml. Proteus mirabilis, P. florescence and E. coli were not inhibited by the methanol extract. The root of E. africana showed strong antibacterial property on some common wound infectious bacteria, thus justifies the traditional use of E. africana in the treatment of wounds and skin infections.
